SOD1-Derlin-1 inhibitor 56-59 |CAS:2170170-27-9 Probechem Biochemicals

Chemical Structure : SOD1-Derlin-1 inhibitor 56-59

CAS No.: 2170170-27-9

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SOD1-Derlin-1 inhibitor 56-59 (Compound 56-59)

货号: PC-35376Not For Human Use, Lab Use Only.

SOD1-Derlin-1 inhibitor 56-59 is a cell-permeable, small molecule inhibitor of SOD1-Derlin-1 interaction, target SOD1 DBR and clearly attenuates the interactions of Derlin-1 with 122 types of SOD1mut in the cell-based co-immunoprecipitation assays.

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25 mg	￥6580	In stock
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生物&药学活性

SOD1-Derlin-1 inhibitor 56-59 is a cell-permeable, small molecule inhibitor of SOD1-Derlin-1 interaction, target SOD1 DBR and clearly attenuates the interactions of Derlin-1 with 122 types of SOD1mut in the cell-based co-immunoprecipitation assays.
SOD1-Derlin-1 inhibitor 56-59 significantly ameliorates the ALS pathology both in motoneurons derived from patient induced pluripotent stem cells and in model mice.

物理化学性质&存储条件

分子量	386.473
分子式	C22H18N4OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	N-allyl-3-amino-N-phenyl-6-(pyridin-3-yl)thieno[2,3-b]pyridine-2-carboxamide

参考文献

1. Tsuburaya N, et al. Nat Commun. 2018 Jul 10;9(1):2668.

SOD1-Derlin-1 inhibitor 56-59 (Compound 56-59)

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物理化学性质&存储条件

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SOD1-Derlin-1 inhibitor 56-59 (Compound 56-59)

生物&药学活性

物理化学性质&存储条件

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