SOCS1 inhibitor 20 | SOCS1 inhibitor | Probechem Biochemicals

Chemical Structure : SOCS1 inhibitor 20

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SOCS1 inhibitor 20 (MpYTTVAD)

货号: PC-72813Not For Human Use, Lab Use Only.

SOCS1 inhibitor 20 is a specific, cell-permeable phosphotyrosine peptide that target the SH2 domain of SOCS1 (Suppressor of cytokine signaling 1) with IC50 of 20 nM (hSOCS1)

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生物&药学活性

SOCS1 inhibitor 20 (MpYTTVAD) is a specific, cell-permeable phosphotyrosine peptide that target the SH2 domain of SOCS1 (Suppressor of cytokine signaling 1) with IC50 of 20 nM (hSOCS1).
SOCS1 inhibitor 20 dispalys >100-fold selectivity against the closely related SOCS family proteins CIS, SOCS2/3.
SOCS1 inhibitor 20 stabilize SOCS1 in a thermal shift assay using cell lysates and inhibited SOCS1-mediated ubiquitination of a target substrate in a biochemical assay.

物理化学性质&存储条件

分子量	878.89
分子式	C34H55N8O15PS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Met-pTyr-Thr-Thr-Val-Ala-Asp

参考文献

1. Hao Chen, et al. ACS Chem Biol. 2022 Jan 6. doi: 10.1021/acschembio.1c00884.

SOCS1 inhibitor 20 (MpYTTVAD)

生物&药学活性

物理化学性质&存储条件

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SOCS1 inhibitor 20 (MpYTTVAD)

生物&药学活性

物理化学性质&存储条件

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