欢迎访问ProbeChem中文网站，英文网站请访问www.probechem.com
    英文 |     中文

产品咨询: sales@probechem.com
订购: order@probechem.com

首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-Cyclin-dependent Kinase (CDK)-SNX631
SNX631

Chemical Structure : SNX631

CAS No.: 868066-26-6

加入收藏

SNX631 (SNX-631)

货号: PC-49204Not For Human Use, Lab Use Only.

SNX631 (SNX-631) is a potent, selective inhibitor of CDK8/19 Mediator kinase with IC50 of 10.3 nM in the NF κB-dependent cell-based assays.

规格 价格 库存 数量
25 mg Get quote
50 mg Get quote
100 mg Get quote
获取报价单
* 请选择数量再加入购物车
 or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SNX631 (SNX-631) is a potent, selective inhibitor of CDK8/19 Mediator kinase with IC50 of 10.3 nM in the NF κB-dependent cell-based assays.
    SNX631 is 6 to 10 times more potent than Senexin B in all the assays except for the DiscoverX activesite-dependent competition binding assay.
    SNX631 showed synergistic interactions with lapatinib and trastuzumab in a panel of HER2+ BrCa cell lines, overcoming and preventing resistance to HER2-targeting drugs.
    Combination of HER2-mAb trastuzumab and SNX631 inhibited STAT1 and STAT3 phosphorylation at S727 and up-regulated tumor suppressor BTG2 in HER2+ BrCa cell lines.
    SNX631 partially inhibits growth of xenograft tumors formed by lapatinib-sensitive or -resistant HER2+ breast cancer cells alone, and strongly suppressed by the combination of lapatinib, overcoming lapatinib resistance.

    物理化学性质&存储条件

    分子量 438.550
    分子式 C22H26N6O2S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    3-amino-4-(4-(4-(dimethylcarbamoyl)phenyl)-1,4-diazepan-1-yl)thieno[2,3-b]pyridine-2-carboxamide

    参考文献

    1. Jing Li, et al. Cells. 2019 Oct 6;8(10):1208.

    2. Xiaokai Ding, et al. Proc Natl Acad Sci U S A. 2022 Aug 9;119(32):e2201073119.

    备案号：沪ICP备16042516号-1 Copyright © 2022 probechem.com. All Rights Reserved. probechem Copyright

    联系我们 sales@probechem.com

    Bulk Inquiry

    * Indicates a Required FieldYour information is safe with us.

    • *Product name:
    • *Applicant name:
    • *Email address:
    • *Organization name:
    • *Requested quantity:
    • *Country:
    • *Additional Information:

    询单

    • *产品名称:
    • *姓名:
    • *邮箱:
    • *公司名称:
    • *询单数量:
    • *国籍:
    • 询单信息: