SNX-2112 |CAS:908112-43-6 Probechem Biochemicals

Chemical Structure : SNX-2112

CAS No.: 908112-43-6

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SNX-2112 (PF-04928473, SNX2112)

货号: PC-62491Not For Human Use, Lab Use Only.

SNX-2112 (PF-04928473) is a potent, selective Hsp90 inhibitor with binding IC50 of 30 nM for both HSP90α and HSP90β.

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5 mg	￥1480	In stock
10 mg	￥2380	In stock
25 mg	￥3880	In stock
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100 mg		Get quote

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生物&药学活性

SNX-2112 (PF-04928473) is a potent, selective Hsp90 inhibitor with binding IC50 of 30 nM for both HSP90α and HSP90β.
SNX-2112 shows weak affinity for Hsp90 family members Grp94 and Trap-1 (IC50=0.8-4.2 uM).
SNX-2112 has properties and potency, including degradation of HER2, mutant EGFR, and other client proteins, inhibition of ERK and Akt activation, and induction of a Rb-dependent G1 arrest with subsequent apoptosis.
SNX-2112 is the orally bioavailbe prodrug SNX-5422, inhibits MM cell growth and prolongs survival in a xenograft murine model.

物理化学性质&存储条件

分子量	464.489
分子式	C23H27F3N4O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(6,6-Dimethyl-4-oxo-3-trifluoromethyl-4,5,6,7-tetrahydro-indazol-1-yl)-2-(trans-4-hydroxy-cyclohexylamino)-benzamide

参考文献

1. Okawa Y, et al. Blood. 2009 Jan 22;113(4):846-55.

2. Chandarlapaty S, et al. Clin Cancer Res. 2008 Jan 1;14(1):240-8.

3. Bachleitner-Hofmann T, et al. Clin Cancer Res. 2011 Jan 1;17(1):122-33.

SNX-2112 (PF-04928473, SNX2112)

生物&药学活性

物理化学性质&存储条件

参考文献

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SNX-2112 (PF-04928473, SNX2112)

生物&药学活性

物理化学性质&存储条件

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