SNX-0723 |CAS:1073969-18-2 Probechem Biochemicals

Chemical Structure : SNX-0723

CAS No.: 1073969-18-2

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SNX-0723 (SNX 0723;SNX0723)

货号: PC-60683Not For Human Use, Lab Use Only.

SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM.

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2 mg	￥2480	In stock
5 mg	￥3680	In stock
10 mg	￥5680	In stock
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100 mg		Get quote

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生物&药学活性

SNX-0723 is a selective, brain-permeable, orally acitve small-molecule inhibitor of Hsp90 (IC50=14 nM) that inhibits alpha-synuclein oligomerization with EC50 of 48 nM.
SNX-0723 induces Hsp70 (IC50=31 nM), and decreases expression of several known Hsp90 client proteins:HER2 (IC50=9.4 nM), ribosomal protein s6 (pS6) (IC50=13 nM), and PERK (IC50=5.5 nM).
SNX-0723 shows significant brain concentrations along with induction of brain Hsp70 in vivo with promising PK properties.

物理化学性质&存储条件

分子量	399.47
分子式	C22H26FN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-fluoro-6-[[(3S)-oxolan-3-yl]amino]-4-(3,6,6-trimethyl-4-oxo-5,7-dihydroindol-1-yl)benzamide

参考文献

1. Putcha P, et al. J Pharmacol Exp Ther. 2010 Mar;332(3):849-57.et al.

2. McFarland NR, et al. PLoS One. 2014 Jan 20;9(1):e86048.

3. Neubert T, et al. Bioorg Med Chem Lett. 2015 Mar 15;25(6):1338-42.

SNX-0723 (SNX 0723;SNX0723)

生物&药学活性

物理化学性质&存储条件

参考文献

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SNX-0723 (SNX 0723;SNX0723)

生物&药学活性

物理化学性质&存储条件

参考文献

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