SNT-5382 | LOXL2 inhibitor | Probechem Biochemicals

Chemical Structure : SNT-5382

CAS No.: 2125956-92-3

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SNT-5382 (SNT5382, LOX-IN-4)

货号: PC-24750Not For Human Use, Lab Use Only.

SNT-5382 is a potent, selective and irreversible LOXL2 inhibitor with IC50 of 10 nM, exhibits rapid, time-dependent LOXL2 inhibition and competitively binds to the active site of LOXL2.

规格	价格	库存
5 mg	￥1280	In stock
10 mg	￥1980	In stock
25 mg	￥3480	In stock
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100 mg		Get quote

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生物&药学活性

SNT-5382 is a potent, selective and irreversible LOXL2 inhibitor with IC50 of 10 nM, exhibits rapid, time-dependent LOXL2 inhibition and competitively binds to the active site of LOXL2.

SNT-5382 initially binds to the lysine tyrosylquinone (LTQ) cofactor within the enzymatic pocket, resulting in Schiff base formation and subsequent oxidation.

SNT-5382 also inhibits LOXL3 (IC50=20 nM) and, to a lesser extent, LOXL4 (IC50=118 nM), exhibits good selectivity (> 80-fold) over family members LOX (IC50=833 nM) and LOXL1 (IC50=1710 nM).

SNT-5382 (14 mg/kg/day, oral) reduces the area of collagen volume fraction and improves the ejection fraction in a myocardial infarction model.

物理化学性质&存储条件

分子量	423.93
分子式	C20H23ClFN3O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-4-(2,5-dimethyl-3-(3-(methylsulfonyl)phenyl)-1H-pyrrolo[3,2-b]pyridin-1-yl)-3-fluorobut-2-en-1-amine hydrochloride

参考文献

1. Perryman L, et al. Sci Rep. 2025 Jul 2;15(1):22653.

SNT-5382 (SNT5382, LOX-IN-4)

生物&药学活性

物理化学性质&存储条件

参考文献

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SNT-5382 (SNT5382, LOX-IN-4)

生物&药学活性

物理化学性质&存储条件

参考文献

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