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首页-小分子抑制剂&激动剂-GPCR-Melanocortin Receptor-SNT-207858
SNT-207858

Chemical Structure : SNT-207858

CAS No.: 1104662-66-9

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SNT-207858 (SNT207858)

货号: PC-49761Not For Human Use, Lab Use Only.

SNT-207858 (SNT207858) is a potent, selective, BBB-penetrating, and orally active melanocortin-4 (MC4R) receptor antagonist with binding/fuaction IC50 of 22/11 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SNT-207858 (SNT207858) is a potent, selective, BBB-penetrating, and orally active melanocortin-4 (MC4R) receptor antagonist with binding/fuaction IC50 of 22/11 nM, respectively.
    SNT-207858 treatment increase food intake in healthy mice.
    SNT-207858 prevented tumor induced weight loss, and diminished loss of lean body mass and fat mass.

    物理化学性质&存储条件

    分子量 616.63
    分子式 C32H43Cl2N5O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    N-((R)-3-(2,4-dichlorophenyl)-1-oxo-1-(4-(3-((R)-2-(pyrrolidin-1-yl)butoxy)pyridin-2-yl)piperidin-1-yl)propan-2-yl)pyrrolidine-1-carboxamide

    参考文献

    1. Weyermann P, et al. PLoS One. 2009;4(3):e4774.

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