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首页-小分子抑制剂&激动剂-Cell Cycle/DNA Damage-DNA Repair Protein -SNM1A inhibitor 19
SNM1A inhibitor 19

Chemical Structure : SNM1A inhibitor 19

CAS No.:

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SNM1A inhibitor 19

货号: PC-22445Not For Human Use, Lab Use Only.

SNM1A inhibitor 19 is a cell-active small molecule inhibitor of SNM1A DNA repair nuclease with IC50 of 44 uM, sensitises cancer cells to cisplatin and delays resolution of cisplatin-induced DNA damage.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SNM1A inhibitor 19 is a cell-active small molecule inhibitor of SNM1A DNA repair nuclease with IC50 of 44 uM, sensitises cancer cells to cisplatin and delays resolution of cisplatin-induced DNA damage.

物理化学性质&存储条件

分子量 361.79
分子式 C16H16ClN5O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
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Solubility

10 mM in DMSO
Chemical Name/SMILES

(S)-2-((6-chloro-2-((furan-2-ylmethyl)amino)quinazolin-4-yl)amino)-N-hydroxypropanamide

参考文献

1. Marcin Bielinski, et al. Chem Sci. 2024 Apr 30;15(21):8227-8241.

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