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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Calcium Channel -SN-89B
SN-89B

Chemical Structure : SN-89B

CAS No.:

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SN-89B

货号: PC-23294Not For Human Use, Lab Use Only.

SN-89B is a potent LRRC8 channel inhibitorsuppresses agonist-induced platelet activation and aggregation (IC50=840 nM).

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SN-89B is a potent LRRC8 channel inhibitorsuppresses agonist-induced platelet activation and aggregation (IC50=840 nM).
SN-89B strongly inhibits ATP and ADP efflux elicited in response to hypotonic swelling in MEG-01 cells.
SN-89B significantly reduces agonist-induced human platelet aggregation, as well as phosphorylation of AKT1, AKT2, and GSK-3β.
SN-89B (50 mg/kg) significantly prolongs FeCl3-induced carotid arterial thrombosis in WT C57BL/6J mice.

物理化学性质&存储条件

分子量
分子式
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Tranter JD, et al. bioRxiv [Preprint]. 2024 Sep 26:2024.09.26.615233.

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