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首页-小分子抑制剂&激动剂-Membrane Transporter/Ion Channel-Calcium Channel -SN-407
SN-407

Chemical Structure : SN-407

CAS No.: 2566725-59-3

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SN-407 (SN407)

货号: PC-23293Not For Human Use, Lab Use Only.

SN-407 is a potent Volume-Regulated Anion Channel (VRAC) inhibitor with IC50 of 1.6 uM in HEK cells, targets LRRC8 complex and blocks agonist-induced aggregation, ATP release, and calcium influx in platelets.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SN-407 is a potent Volume-Regulated Anion Channel (VRAC) inhibitor with IC50 of 1.6 uM in HEK cells, targets LRRC8 complex and blocks agonist-induced aggregation, ATP release, and calcium influx in platelets.

物理化学性质&存储条件

分子量 469.44
分子式 C25H34Cl2O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

7-((2-butyl-6,7-dichloro-2-cyclopentyl-1-oxo-2,3-dihydro-1H-inden-5-yl)oxy)heptanoic acid

参考文献

1. Tranter JD, et al. bioRxiv [Preprint]. 2024 Sep 26:2024.09.26.615233.

2. Lauren J Lahey, et al. Mol Cell. 2020 Nov 19;80(4):578-591.e5.

3. Gunasekar SK, et al. Nat Commun. 2022 Feb 10;13(1):784.

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