SN-406 | LRRC8 inhibitor | Probechem Biochemicals

Chemical Structure : SN-406

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SN-406 (SN406)

货号: PC-23292Not For Human Use, Lab Use Only.

SN-406 is a potent potent VRAC LRRC8 channels inhibitor with IC50 of 3.1 uM in HEK cells, suppress agonist-induced aggregation, ATP release, and calcium influx.

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生物&药学活性

SN-406 is a potent potent VRAC LRRC8 channels inhibitor with IC50 of 3.1 uM in HEK cells, suppress agonist-induced aggregation, ATP release, and calcium influx.
SN-406 inhibit thrombin-stimulated platelet aggregation on LRRC8-mediated ATP currents in patch-clamp studies. reduces both thrombin- and PAR4-AP- stimulated Ca2+ flux.
SN-406 significantly suppresses human platelet aggregation in response to PAR1+PAR4 stimulation and impairs agonist-induced Ca2+ signaling in mouse platelets.
SN-406 exhibits a clear dose-response relationship in PAR4-AP-induced mouse platelet aggregation with IC50 of 1.1 uM.
LRRC8A (leucine-rich repeat-containing protein 8A, also known as SWELL1) is the essential subunit of the heterohexameric LRRC8 volume-regulated anion channel (VRAC), which contain at least one LRRC8A subunit in combination with, B, C, D and/or E subunits.

物理化学性质&存储条件

分子量	469.44
分子式	C25H34Cl2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-((6,7-dichloro-2-cyclopentyl-1-oxo-2-pentyl-2,3-dihydro-1H-inden-5-yl)oxy)hexanoic acid

参考文献

1. Gunasekar SK, et al. Nat Commun. 2022 Feb 10;13(1):784.

2. Lauren J Lahey, et al. Mol Cell. 2020 Nov 19;80(4):578-591.e5.

3. Tranter JD, et al. bioRxiv [Preprint]. 2024 Sep 26:2024.09.26.615233.

SN-406 (SN406)

生物&药学活性

物理化学性质&存储条件

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SN-406 (SN406)

生物&药学活性

物理化学性质&存储条件

参考文献

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