SMYD3 inhibitor 29

Chemical Structure : SMYD3 inhibitor 29

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货号: PC-72992Not For Human Use, Lab Use Only.

SMYD3 inhibitor 29 is a highly potent, selective, covalent inhibitor of histone methyltransferase SMYD3 with IC50 of 1.7 nM.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SMYD3 inhibitor 29 is a highly potent, selective, covalent inhibitor of histone methyltransferase SMYD3 with IC50 of 11.7 nM.
SMYD3 inhibitor 29 exhibits high potency by inhibiting SMYD3's enzymatic activity and showing antiproliferative activity against HepG2 in 3D cell culture (GI50=1.04 uM).
SMYD3 inhibitor 29 inhibits cellular MAP3K2 methylation.
SMYD3 inhibitor 29 displayed high selectivity when tested against a panel of methyltransferases, namely, SMYD1-2, G9a, PRDM9, and PRMT5.

物理化学性质&存储条件

分子量	491.032
分子式	C28H31ClN4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(R)-1-(4-(2-(4-(1-aminocyclopropyl)phenyl)-4-chloroquinoline-7-carbonyl)-2-methylpiperazin-1-yl)butan-1-one

参考文献

1. Huang C, et al. ACS Med Chem Lett. 2019 May 23;10(6):978-984.