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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-SMU127
SMU127

Chemical Structure : SMU127

CAS No.: 903864-87-9

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SMU127 (SMU-127;ZINC666243)

货号: PC-35705Not For Human Use, Lab Use Only.

SMU127 (SMU-127, ZINC666243) is a specific TLR1-TLR2 small molecule agonist with EC50 of 0.55 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SMU127 (SMU-127, ZINC666243) is a specific TLR1-TLR2 small molecule agonist with EC50 of 0.55 uM.
    SMU127 stimulates NF-κB activation and promotes TNFα secretion in human macrophages and mononuclear cells, inhibits the growth of breast cancer tumors in BABL/c mice.

    物理化学性质&存储条件

    分子量 337.438
    分子式 C16H23N3O3S
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    ethyl 2-(4-methylpiperazine-1-carboxamido)-5,6-dihydro-4H-cyclopenta[b]thiophene-3-carboxylate

    参考文献

    1. Chen Z, et al. Chem Commun (Camb). 2018 Oct 9;54(81):11411-11414.

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