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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-SMU-Z1
SMU-Z1

Chemical Structure : SMU-Z1

CAS No.: 2410782-66-8

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SMU-Z1 (TLR1/TLR2 agonist)

货号: PC-49018Not For Human Use, Lab Use Only.

SMU-Z1 is a potent, specific small molecule agonist of TLR1/2, specifically activates TLR2 through its association with TLR1, induces NF‐κB activation in HEK‐Blue hTLR2 cells with EC50 of 4.88 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SMU-Z1 is a potent, specific small molecule agonist of TLR1/2, specifically activates TLR2 through its association with TLR1, induces NF‐κB activation in HEK‐Blue hTLR2 cells with EC50 of 4.88 nM.
    SMU‐Z1 specifically activates TLR1/2 but not TLR2/6 signaling.
    SMU‐Z1 (10-1,000 nM) stimulates a strong TNF‐α and IL‐1β production in a dose‐response manner in both mouse cells and human PBMC cultures, significantly increases IL‐6 mRNA level in human PBMC, upregulates IL‐6 synthesis about 100 fold.
    SMU‐Z1 specifically simulates TLR1 and TLR2 through the NF‐κB pathway to trigger the synthesis of proinflammatory cytokines, such as TNF‐α, IL‐1β, IL‐6 and nitric oxide.
    SMU‐Z1 promotes splenocyte proliferation, up‐regulates the expression of CD8+ T, NK and DC cells, which in turn resulted in antitumor immunity against leukemia in vivo.
    SMU-Z1 can both enhance HIV-1 transcription and promote NK cell-mediated inhibition of HIV-1-infected autologous CD4+ T cells.

    物理化学性质&存储条件

    分子量 378.311
    分子式 C17H13F3N4O3
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(1-(2-(methylamino)-5-nitrophenyl)-1H-imidazol-4-yl)-5-(trifluoromethyl)phenol

    参考文献

    1. Cen X, et al. Adv Sci (Weinh). 2019 Mar 27;6(10):1802042.

    2. Duan S, et al. J Virol. 2021 Aug 10;95(17):e0081621.

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