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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-SMU-Z1
SMU-Z1

Chemical Structure : SMU-Z1

CAS No.: 2410782-66-8

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SMU-Z1 (TLR1/TLR2 agonist)

货号: PC-49018Not For Human Use, Lab Use Only.

SMU-Z1 is a potent, specific small molecule agonist of TLR1/2, specifically activates TLR2 through its association with TLR1, induces NF-κB activation in HEK-Blue hTLR2 cells with EC50 of 4.88 nM.

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10 mg ￥4580 In stock
25 mg ￥7280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SMU-Z1 is a potent, specific small molecule agonist of TLR1/2, specifically activates TLR2 through its association with TLR1, induces NF-κB activation in HEK-Blue hTLR2 cells with EC50 of 4.88 nM.
SMU-Z1 specifically activates TLR1/2 but not TLR2/6 signaling.
SMU-Z1 (10-1,000 nM) stimulates a strong TNF-α and IL-1β production in a dose-response manner in both mouse cells and human PBMC cultures, significantly increases IL-6 mRNA level in human PBMC, upregulates IL-6 synthesis about 100 fold.
SMU-Z1 specifically simulates TLR1 and TLR2 through the NF-κB pathway to trigger the synthesis of proinflammatory cytokines, such as TNF-α, IL-1β, IL-6 and nitric oxide.
SMU-Z1 promotes splenocyte proliferation, up-regulates the expression of CD8+ T, NK and DC cells, which in turn resulted in antitumor immunity against leukemia in vivo.
SMU-Z1 can both enhance HIV-1 transcription and promote NK cell-mediated inhibition of HIV-1-infected autologous CD4+ T cells.

物理化学性质&存储条件

分子量 378.311
分子式 C17H13F3N4O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-(1-(2-(methylamino)-5-nitrophenyl)-1H-imidazol-4-yl)-5-(trifluoromethyl)phenol

参考文献

1. Cen X, et al. Adv Sci (Weinh). 2019 Mar 27;6(10):1802042.

2. Duan S, et al. J Virol. 2021 Aug 10;95(17):e0081621.

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