SMU-CX1 | TLR3 inhibitor | Probechem Biochemicals

Chemical Structure : SMU-CX1

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SMU-CX1 (NSC69187)

货号: PC-25126Not For Human Use, Lab Use Only.

SMU-CX1 is a specific TLR3 inhibitor, inhibits TLR3-mediated SEAP signaling with IC50 of 0.11 uM, inhibits influenza A virus (IAV) and SARS-CoV-2 activity.

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生物&药学活性

SMU-CX1 is a specific TLR3 inhibitor, inhibits TLR3-mediated SEAP signaling with IC50 of 0.11 uM, inhibits influenza A virus (IAV) and SARS-CoV-2 activity.
SMU-CX1 selectively inhibits TLR3-activated NO signals but not that of other homologous TLRs.
SMU-CX1 significantly reduces the expression of inflammatory factors downstream of TLR3 signaling pathway induced by IAV stimulation.
SMU-CX1 inhibits SARS-CoV-2 in Vero-E6 cells with IC50 of 0.43 uM.
MU-CX1 exhibits good inhibitory activity against influenza A virus with IC50 ranged from 0.14 to 0.33 µM.
SMU-CX1 significantly inhibits PB2 and NP protein of IAV, can also inhibit inflammatory factors in host cells including IFN-β, IP-10 and CCL-5.

物理化学性质&存储条件

分子量	276.34
分子式	C18H16N2O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	9-Methoxy-5,11-dimethyl-6H-pyrido[4,3-b]carbazole

参考文献

1. Yue Pan, et al. Bioorg Med Chem Lett. 2024 Mar 15:101:129672.

SMU-CX1 (NSC69187)

生物&药学活性

物理化学性质&存储条件

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SMU-CX1 (NSC69187)

生物&药学活性

物理化学性质&存储条件

参考文献

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