SMT-738 | LolCDE inhibitor | Probechem Biochemicals

Chemical Structure : SMT-738

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SMT-738 (SMT738)

货号: PC-21552Not For Human Use, Lab Use Only.

SMT-738 is a small-molecule inhibitor of bacterial lipoprotein transport complex (LolCDE), shows potent and highly selective antimicrobial activity.

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生物&药学活性

SMT-738 is a small-molecule inhibitor of bacterial lipoprotein transport complex (LolCDE), shows potent and highly selective antimicrobial activity.
SMT-738 shows potent in vitro activity across all the clinical isolates with MIC90 values of 1 µg/mL against E. coli and 2 µg/mL against K. pneumoniae.
SMT-738 displays potent antimicrobial activity against clinically relevant strains of Enterobacteriaceae and exerts its bactericidal activity via a mechanism distinct from that of known classes of antibiotics.
SMT-738 acts by disruption of LolCDE complex activity.
SMT-738 demonstrates robust efficacy in multiple murine in vivo infection models (bloodstream/pneumonia/urinary tract).

物理化学性质&存储条件

分子量	392.46
分子式	C21H24N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-amino-1-(6-(2-amino-5-(3-methylpyridin-4-yl)-1H-imidazol-4-yl)-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)-2-methylpropan-1-one

参考文献

1. Patent WO 2022/233886 A1

2. Breidenstein EBM, et al. Antimicrob Agents Chemother. 2023 Dec 12:e0069523.

SMT-738 (SMT738)

生物&药学活性

物理化学性质&存储条件

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SMT-738 (SMT738)

生物&药学活性

物理化学性质&存储条件

参考文献

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