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首页-小分子抑制剂&激动剂-Others-Other Targets-SMS121
SMS121

Chemical Structure : SMS121

CAS No.: 949875-48-3

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SMS121 (SMS-121)

货号: PC-22176Not For Human Use, Lab Use Only.

SMS121 (SMS-121) is a drug-like small molecule inhibitor of the very long/long chain fatty acid transporter CD36 (FAT, scavenger receptor class B member 3/SCARB3) with binding Kd of 5.57 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SMS121 (SMS-121) is a drug-like small molecule inhibitor of the very long/long chain fatty acid transporter CD36 (FAT, scavenger receptor class B member 3/SCARB3) with binding Kd of 5.57 uM.
    SMS121 affects the viability of KG-1 cells with IC50 of 156 uM, impairs lipid uptake and reduce the viability in AML cells.

    物理化学性质&存储条件

    分子量 355.39
    分子式 C20H21NO5
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (E)-2-(4-(3-(4-(dimethylamino)phenyl)-3-oxoprop-1-en-1-yl)-2-methoxyphenoxy) acetic acid

    参考文献

    1. Åbacka H, et al. Sci Rep. 2024 Apr 20;14(1):9104.

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