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首页-小分子抑制剂&激动剂-Others-CaMK-SMP-114
SMP-114

Chemical Structure : SMP-114

CAS No.: 215174-50-8

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SMP-114 (Rimacalib, SMP114)

货号: PC-21505Not For Human Use, Lab Use Only.

SMP-114 (Rimacalib) is a potent, specific and orally available CaMKII inhibitor with potential for treatment of rheumatoid arthritis.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SMP-114 (Rimacalib) is a potent, specific and orally available CaMKII inhibitor with potential for treatment of rheumatoid arthritis.
SMP-114 significantly reduces SR Ca2+ leak in human atrial and failing left ventricular as well as in murine ventricular cardiomyocytes.
SMP-114 demonstrates potential to treat SR Ca2+ leak and consequently proarrhythmogenic events in rodent as well as in human atrial cardiomyocytes and cardiomyocytes from patients with heart failure.

物理化学性质&存储条件

分子量 394.45
分子式 C22H23FN4O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N'-[3-[(1S)-1-(3-fluoro-4-phenylphenyl)ethyl]-1,2-oxazol-5-yl]morpholine-4-carboximidamide

参考文献

1. Westra J, et al. Ann N Y Acad Sci. 2009 Sep;1173:706-11.

2. Neef S, et al. Basic Res Cardiol. 2017 Jul;112(4):45.

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