SMM-189 | CB2 inverse agonist | Probechem Biochemicals

Chemical Structure : SMM-189

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SMM-189 (SMM189)

货号: PC-22115Not For Human Use, Lab Use Only.

SMM-189 is a selective cannabinoid receptor 2 (CB2) inverse agonist with Ki of 121.3 nM, 40-fold selective over CB1 receptor.

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生物&药学活性

SMM-189 is a selective cannabinoid receptor 2 (CB2) inverse agonist with Ki of 121.3 nM, 40-fold selective over CB1 receptor.
SMM-189 prevents the rat primary microglia-mediated inflammation and shows moderate neuroprotection against N-methyl-D-aspartic acid (NMDA) receptor-mediated excitotoxicity in rat primary hippocampal cultures containing both neurons and glia.
SMM-189 (6 mg/kg, i.p., b.i.d.) prevented the seizure-induced cytokine surge in the brain, neuronal death, and behavioral impairments 24 h after status epilepticus (SE).
SMM-189 shows potential for the treatment of neurodegenerative disorders and traumatic brain injury.

物理化学性质&存储条件

分子量	359.20
分子式	C19H12Cl2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(3',5'-dichloro-2,6-dihydroxy-[1,1'-biphenyl]-4-yl)(phenyl)methanone

参考文献

1. Alghamdi SS, et al. Bioorg Med Chem. 2021 Mar 1;33:116035.

2. Yu Y, et al. Mol Neurobiol. 2020 Jun;57(6):2830-2845.

3. Presley C, et al. Pharmacol Res Perspect. 2015 Aug;3(4):e00159.

SMM-189 (SMM189)

生物&药学活性

物理化学性质&存储条件

参考文献

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SMM-189 (SMM189)

生物&药学活性

物理化学性质&存储条件

参考文献

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