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首页-小分子抑制剂&激动剂-Others-Other Targets-SMIP004-7
SMIP004-7

Chemical Structure : SMIP004-7

CAS No.: 72072-16-3

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SMIP004-7 (SMIP 004-7)

货号: PC-72545Not For Human Use, Lab Use Only.

SMIP004-7 is a small molecule inhibitor of mitochondrial respiration with selective in vivo anti-cancer activity, targets drug-resistant cancer cells with stem-like features by inhibiting NADH:ubiquinone oxidoreductase (complex I).

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25 mg ￥1880 In stock
100 mg ￥3880 In stock
250 mg ￥5580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SMIP004-7 is a small molecule inhibitor of mitochondrial respiration with selective in vivo anti-cancer activity, targets drug-resistant cancer cells with stem-like features by inhibiting NADH:ubiquinone oxidoreductase (complex I).
SMIP004-7 suppressed colony formation against various prostate (LNCaP, 22RV1,LAPC4), colon cancer (HCT116), and mouse triple-negative breast cancer (4T1) cell lines.
SMIP004-7 inhibits NADH oxidation activity and tumor hypoxia in vivo, promotes cancer immune surveillance.
SMIP004-7 stabilizes NDUFS2 in cells, NDUFS2 appears to play a unique role in the mechanism of SMIP004-7.

物理化学性质&存储条件

分子量 163.264
分子式 C11H17N
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-butyl-2-methylaniline

参考文献

1. Shashi Jain, et al. Cell Chem Biol. 2021 Nov 23;S2451-9456(21)00479-7.

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