SMIP-031 | PPM1A inhibitor | Probechem Biochemicals

Chemical Structure : SMIP-031

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SMIP-031 (SMIP031)

货号: PC-22546Not For Human Use, Lab Use Only.

SMIP-031 is a potent small molecule inhibitor of metal-dependent phosphatase PPM1A with IC50 of 180 nM, efficiently activates autophagy and reduces the mycobacterium tuberculosis (Mtb) infection.

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生物&药学活性

SMIP-031 is a potent small molecule inhibitor of metal-dependent phosphatase PPM1A with IC50 of 180 nM, efficiently activates autophagy and reduces the mycobacterium tuberculosis (Mtb) infection.
SMIP-031 efficiently increased the level of phosphorylation of S403-p62 and the expression of LC3B-II to activate autophagy, resulting in the dose-dependent clearance of Mtb in infected macrophages.
SMIP-031 possesses a good pharmacokinetic profile and oral bioavailability (F = 74%).
SMIP-031 is well tolerated up to 50 mg/kg and significantly reduces the bacteria burden in the spleens of infected mice.

物理化学性质&存储条件

分子量	366.23
分子式	C17H17BrFNO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-Ethoxy-2-fluoro-5-(2-hydroxyethyl)phenanthridin-5-ium bromide

参考文献

1. Zhipeng Yu, et al. J Med Chem. 2024 Jul 3. doi: 10.1021/acs.jmedchem.4c00513.

SMIP-031 (SMIP031)

生物&药学活性

物理化学性质&存储条件

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SMIP-031 (SMIP031)

生物&药学活性

物理化学性质&存储条件

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