SMIFH2 |CAS:340316-62-3 Probechem Biochemicals

Chemical Structure : SMIFH2

CAS No.: 340316-62-3

加入收藏

SMIFH2 (SMIFH 2)

货号: PC-62426Not For Human Use, Lab Use Only.

SMIFH2 is a small molecule formin homology 2 domains inhibitor of formin-mediated actin assembly, targets formins from evolutionarily diverse organisms including yeast, nematode worm, and mice with IC50s of 5-15 uM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SMIFH2 is a small molecule formin homology 2 domains inhibitor of formin-mediated actin assembly, targets formins from evolutionarily diverse organisms including yeast, nematode worm, and mice with IC50s of 5-15 uM.
SMIFH2 prevents both formin nucleation and processive barbed end elongation and decreases formin's affinity for the barbed end.
SMIFH2 disrupts formin-dependent, but not Arp2/3 complex-dependent, actin cytoskeletal structures in fission yeast and mammalian NIH 3T3 fibroblasts at low micromolar concentrations.

物理化学性质&存储条件

分子量	377.212
分子式	C15H9BrN2O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-Bromophenyl)-5-(2-furanylmethylene)dihydro-2-thioxo-4,6(1H,5H)-pyrimidinedione

参考文献

1. Rizvi SA, et al. Chem Biol. 2009 Nov 25;16(11):1158-68.

2. Ziske MA, et al. Biochem Biophys Res Commun. 2016 Mar 25;472(1):33-9.

3. Borinskaya S, et al. Mol Biol Cell. 2016 Jan 15;27(2):247-59.

4. Isogai T, et al. Sci Rep. 2015 Apr 30;5:9802.

SMIFH2 (SMIFH 2)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SMIFH2 (SMIFH 2)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.