SMER28 | VCP/p97 activator | Probechem Biochemicals

Chemical Structure : SMER28

CAS No.: 307538-42-7

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SMER28 (SMER-28)

货号: PC-42080Not For Human Use, Lab Use Only.

SMER28 is a small-molecule enhancer/inducer of Autophagy, SMER28 is a small molecule activator of VCP/p97.

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10 mg	￥680	In stock
25 mg	￥1180	In stock
50 mg	￥2180	In stock
100 mg		Get quote

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生物&药学活性

SMER28 is a small-molecule enhancer/inducer of Autophagy, SMER28 is a small molecule activator of VCP/p97.
SMER28 decreases the levels of Aβ peptide (EC50=10 uM) and APP-CTF (EC50 of 20 uM) in a γ-secretase-independent manner in primary neuronal cultures, Atg5, Beclin1 and Ulk1 are shown to be involved in the degradation of Aβ and APP-CTF.
SMER28 enhances erythropoiesis in a range of in vitro and in vivo models of DBA, and protects against neurodegeneration in Drosophila model of Huntington’s disease.

物理化学性质&存储条件

分子量	264.1212
分子式	C11H10BrN3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 32 mg/mL
Chemical Name/SMILES	4-Quinazolinamine, 6-bromo-N-2-propen-1-yl-

参考文献

1. Doulatov S, et al. Sci Transl Med. 2017 Feb 8;9(376). pii: eaah5645.

2. Rosenthal AK, et al. J Biol Chem. 2015 May 22;290(21):13028-38.

3. Sarkar S, et al. Nat Chem Biol. 2007 Jun;3(6):331-8.

4. Tian Y et al. FASEB J. 2011 Jun;25(6):1934-42.

SMER28 (SMER-28)

生物&药学活性

物理化学性质&存储条件

参考文献

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SMER28 (SMER-28)

生物&药学活性

物理化学性质&存储条件

参考文献

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