SMC18 | CD47/SIRPα, PD-1/PD-L1 inhibitor | Probechem Biochemicals

Chemical Structure : SMC18

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SMC18 (SMC 18)

货号: PC-21925Not For Human Use, Lab Use Only.

SMC18 is a specific small molecule CD47/SIRPα and PD-1/PD-L1 dual inhibitor, effectively blocks the CD47/SIRPα and PD-1/PD-L1 interactions with IC50 of 17.8 and 19.7 uM (human SIRPα and hPD-L1) respectively.

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生物&药学活性

SMC18 is a specific small molecule CD47/SIRPα and PD-1/PD-L1 dual inhibitor, effectively blocks the CD47/SIRPα and PD-1/PD-L1 interactions with IC50 of 17.8 and 19.7 uM (human SIRPα and hPD-L1) respectively.
SMC18 binds SIRPα and PD-L1 to block CD47/SIRPα and PD-1/PD-L1 interaction.
SMC18 does not impede the hTIGIT/hPVR, hLAG-3/hFGL-1, hCD112R/hCD112, and hTIM-3/hGal-9 pathways.
SMC18 effectively enhances the macrophages-mediated phagocytosis of tumor cells.
SMC18 effectively inhibits the phosphorylation of PD-1 and restores T cell function.
SMC18 (6 mg/kg) significantly inhibits MC38 tumor growth and triggers antitumor immune response, shows no hematotoxicity and hepatotoxicity.
SMC18 exhibits synergistic inhibition of MC38 tumor growth by combining with radiotherapy.

物理化学性质&存储条件

分子量	475.56
分子式	C26H25N3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-[(3,5-dimethylphenyl)sulfamoyl]-4-oxo-N-(2-phenylethyl)-1,4-dihydroquinoline-3-carboxamide

参考文献

1. Jin S, et al. Cell Commun Signal. 2024 Mar 11;22(1):173.

SMC18 (SMC 18)

生物&药学活性

物理化学性质&存储条件

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SMC18 (SMC 18)

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物理化学性质&存储条件

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