SMC-21598 | CCL8 inhibitor | Probechem Biochemicals

Chemical Structure : SMC-21598

CAS No.: 3392-07-2

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SMC-21598 (SMC21598)

货号: PC-49404Not For Human Use, Lab Use Only.

SMC-21598 is a specific small molecule CCL18 antagonist, binds with high-afnity on the CCL18 protein in 1:1 stoichiometry with ITC KD value of 600 nM, blocks the binding of CCL18 with its receptor PITPNM3.

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5 mg	￥1880	In stock
10 mg	￥2980	In stock
25 mg	￥4580	In stock
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生物&药学活性

SMC-21598 is a specific small molecule CCL18 antagonist, binds with high-afnity on the CCL18 protein in 1:1 stoichiometry with ITC KD value of 600 nM, blocks the binding of CCL18 with its receptor PITPNM3.
SMC-21598 does not inhibit TGF-β, CXCL12, and EGF -induced cell migration.
SMC-21598 inhibited CCL18 induced cell migration in a concentration dependent manner with IC50 value of 130±70 nM for MDA-MB-231 cells.
SMC-21598 (10 uM) significantly inhibited CCL18-induced breast cancer cells adherence, invasiveness, and migration.
SMC-21598 did not significantly affect xenografts growth, but inhibited lung metastasis.

物理化学性质&存储条件

分子量	272.257
分子式	C11H16N2O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2,5-dioxopyrrolidin-1-yl (tert-butoxycarbonyl)glycinate

参考文献

1. Liu Y, et al. Clin Exp Metastasis. 2019 Jun;36(3):243-255.

SMC-21598 (SMC21598)

生物&药学活性

物理化学性质&存储条件

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SMC-21598 (SMC21598)

生物&药学活性

物理化学性质&存储条件

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