SMBA1 |CAS:906440-37-7 Probechem Biochemicals

Chemical Structure : SMBA1

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SMBA1 (SMBA 1;SMBA-1;NSC 408730)

货号: PC-60925Not For Human Use, Lab Use Only.

SMBA1 is a potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation.

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生物&药学活性

SMBA1 is a potent, and selective Bax agonist (Ki=43.3 nM) that induces conformational changes in Bax by blocking S184 phosphorylation.
SMBA1 shows no affinity for other Bcl2 family members, including Bcl2, Bcl-XL, Mcl-1, Bcl-w, Bfl-1/A1, Bid or Bak.
SMBA1 facilitates Bax insertion into mitochondrial membranes and forming Bax oligomers, leads to cytochrome c release and apoptosis in human lung cancer cells.
SMBA1 potently suppresses lung tumour growth via apoptosis by selectively activating Bax in vivo without significant normal tissue toxicity.

物理化学性质&存储条件

分子量	315.32
分子式	C20H13NO3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-2-((2-nitro-9H-fluoren-9-ylidene)methyl)phenol

参考文献

1. Xin M, et al. Nat Commun. 2014 Sep 17;5:4935.

2. Daniele S, et al. ACS Chem Neurosci. 2017 Apr 11. doi: 10.1021/acschemneuro.7b00023.

3. Li R, et al. Cancer Res. 2017 Jun 1;77(11):3001-3012.

4. Levesley J, et al. Neuro Oncol. 2017 Jul 20. doi: 10.1093/neuonc/nox134.

SMBA1 (SMBA 1;SMBA-1;NSC 408730)

生物&药学活性

物理化学性质&存储条件

参考文献

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SMBA1 (SMBA 1;SMBA-1;NSC 408730)

生物&药学活性

物理化学性质&存储条件

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