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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Toll-like Receptor (TLR)-SM360320
SM360320

Chemical Structure : SM360320

CAS No.: 226907-52-4

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SM360320 (CL-087, 1V136)

货号: PC-72050Not For Human Use, Lab Use Only.

SM360320 (CL-087, 1V136) is a potent, orally active and selective TLR7 agonist (ligand).

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5 mg ￥2280 In stock
10 mg ￥3680 In stock
25 mg ￥5780 In stock
50 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SM360320 (CL-087, 1V136) is a potent, orally active and selective TLR7 agonist (ligand).
SM360320 inhibited HCV replication in Huh-7 cells in a dose-dependent manner in the Huh-7 replicon system, reduced HCV mRNA and protein levels in isolated Huh-7 hepatocytes.
SM360320 induced in vivo secretion of interferon alpha (IFNalpha) and exerted a significant antitumor effect in CEA.Tg mice challenged with a syngenic tumor cell line expressing CEA.
SM360320 exerts significant antitumor effects and can act in association with DNA-EP for CEA-positive colon cancer and HER2-positive mammary carcinoma.
Repeated low dose administration of SM360320 induced hyporesponsiveness or tolerance to TLR2, -7, and -9 activators and limited the course of neural inflammation in an experimental allergic encephalomyelitis model.

物理化学性质&存储条件

分子量 C15H17N5O3
分子式 315.333
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

9-benzyl-8-hydroxy-2-(2-methoxyethoxy)adenine

参考文献

1. Lee J, et al. Proc Natl Acad Sci U S A. 2006 Feb 7;103(6):1828-33.

2. Keith B Gorden, et al. J Immunol. 2005 Feb 1;174(3):1259-68.

3. Hayashi T, et al. Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2764-9.

4. Russo C, et al. Blood. 2011 May 26;117(21):5683-91.

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