SM15685 | DYRK1A/B inhibitor | Probechem Biochemicals

Chemical Structure : SM15685

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SM15685 (SM-15685)

货号: PC-23759Not For Human Use, Lab Use Only.

SM15685 is a highly selective and potent, oral, brain-penetrant DYRK1A/B inhibitor with IC50 of 1 nM (DYRK1A).

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生物&药学活性

SM15685 is a highly selective and potent, oral, brain-penetrant DYRK1A/B inhibitor with IC50 of 1 nM (DYRK1A).
SM15685 exhibits high potency, selectivity against the closely related CLKs and GSK3β, and good oral PK profiles characterized by brain-penetration, only inhibits <2% of the full kinome.
SM15685 exhibits IC50 of 18 nM and 55 nM for DYRK1A and DYRK1B respectively in cellular target engagement assays.
SM15685 reduced pTau at the Threonine 212 site (IC50 = 14 nM).
SM15685 at 45mg/kg showed significant reduction of pTau in both subcortical and spinal cord fractions in pharmacodynamic AD model.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES

参考文献

1. Mak CC, et al. Alzheimers Dement. 2025 Jan 9;20(Suppl 6):e087795.

SM15685 (SM-15685)

生物&药学活性

物理化学性质&存储条件

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SM15685 (SM-15685)

生物&药学活性

物理化学性质&存储条件

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