SM15

Chemical Structure : SM15

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货号: PC-27735Not For Human Use, Lab Use Only.

SM15 is a small molecule targeting microtubule-Hec1 interaction, inhibits cancer cell growth through microtubule stabilization, binds the MT surface independently from Hec1 and acts as a stabilizer of both microtubules (MTs) and kinetochore (KT)-microtubule (MT) interactions.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SM15 is a small molecule targeting microtubule-Hec1 interaction, inhibits cancer cell growth through microtubule stabilization, binds the MT surface independently from Hec1 and acts as a stabilizer of both microtubules (MTs) and kinetochore (KT)-microtubule (MT) interactions.
SM15 shows IC50 of 6.0 uM in HeLa cells.
SM15 binds to MTs with a higher affinity with respect to tubulin dimers (KD=0.94 uM and 1.80 uM, respectively).
SM15 induces arrested HeLa cells in the G2/M phases of the cell cycle efficiently.
SM15 induces cell death in tumor cell lines both by mitotic catastrophe and by apoptotic cell death directly from interphase.
SM15 (10 mg/kg) exerts anti-tumor activity, inhibits HeLa tumor growth in vivo.

物理化学性质&存储条件

分子量	467.41
分子式	C25H27BrN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-1-(4-bromophenyl)-3-(1-(2-hydroxy-3-(piperidin-1-yl)propyl)-1H-indol-3-yl)prop-2-en-1-one

参考文献

1. Pellegrini FR, et al. Autophagy. 2023 Jul;19(7):2078-2093.

2. Ferrara M, et al. Oncogene. 2018 Jan 11;37(2):231-240.

SM15

生物&药学活性

物理化学性质&存储条件

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SM15

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