SM142 | Mpro/CatL inhibitor | Probechem Biochemicals

Chemical Structure : SM142

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SM142 (SM-142)

货号: PC-28225Not For Human Use, Lab Use Only.

SM142 is a potent, selective peptidomimetic dual inhibitor of SARS-CoV-2 main protease (MPro) and host cathepsin L (CatL) with IC50 of 1.8 uM and 0.145 uM respectively.

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生物&药学活性

SM142 is a potent, selective peptidomimetic dual inhibitor of SARS-CoV-2 main protease (MPro) and host cathepsin L (CatL) with IC50 of 1.8 uM and 0.145 uM respectively.
SM142 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC50 of 14.7 nM.
SM142 does not inhibit the other cysteine protease, papain-like protease (PLPro) and CatL.
SM142 reduced viral replication, viral loads in the lung, and enhanced survival in SARS-CoV2 infected K18-ACE2 transgenic mice.

物理化学性质&存储条件

分子量	638.74
分子式	C34H43FN4O7
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (6R,9S,12S,E)-9-benzyl-6-(4-fluorobenzyl)-2,2-dimethyl-4,7,10-trioxo-12-(((S)-2-oxopyrrolidin-3-yl)methyl)-3-oxa-5,8,11-triazapentadec-13-en-15-oate

参考文献

1. Mondal S, et al. J Am Chem Soc. 2022 Nov 23;144(46):21035-21045.

SM142 (SM-142)

生物&药学活性

物理化学性质&存储条件

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SM142 (SM-142)

生物&药学活性

物理化学性质&存储条件

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