SM141 | Mpro/CatL inhibitor | Probechem Biochemicals

Chemical Structure : SM141

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SM141 (SM-141)

货号: PC-28224Not For Human Use, Lab Use Only.

SM141 is a potent, selective peptidomimetic dual inhibitor of SARS-CoV-2 main protease (MPro) and host cathepsin L (CatL) with IC50 of 0.9 uM and 0.06 uM respectively.

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生物&药学活性

SM141 is a potent, selective peptidomimetic dual inhibitor of SARS-CoV-2 main protease (MPro) and host cathepsin L (CatL) with IC50 of 0.9 uM and 0.06 uM respectively.
SM141 blocks SARS-CoV2 replication in hACE2 expressing A549 cells with IC50 of 8.2 nM.
SM141 does not inhibit the other cysteine protease, papain-like protease (PLPro) and CatL.
SM141 reduced viral replication, viral loads in the lung, and enhanced survival in SARS-CoV2 infected K18-ACE2 transgenic mice.

物理化学性质&存储条件

分子量	520.63
分子式	C29H36N4O5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	ethyl (S,E)-4-((S)-2-((R)-2-amino-3-phenylpropanamido)-3-phenylpropanamido)-5-((S)-2-oxopyrrolidin-3-yl)pent-2-enoate

参考文献

1. Mondal S, et al. J Am Chem Soc. 2022 Nov 23;144(46):21035-21045.

SM141 (SM-141)

生物&药学活性

物理化学性质&存储条件

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SM141 (SM-141)

生物&药学活性

物理化学性质&存储条件

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