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首页-小分子抑制剂&激动剂-Tyrosine Kinase-Src-SM1-71
SM1-71

Chemical Structure : SM1-71

CAS No.: 2088179-99-9

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SM1-71 (SM 1-71)

货号: PC-72223Not For Human Use, Lab Use Only.

SM1-71 is a multi-targeted acrylamide-modified inhibitor that covalently inhibits 23 kinases including MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC (IC50=4 nM), YES1, FGFR1 (IC50=54 nM), ZAK (MLTK), MAP3K1, LIMK1 and RSK2.

规格 价格 库存 数量
10 mg ￥1180 In stock
25 mg ￥1980 In stock
50 mg ￥3480 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SM1-71 is a multi-targeted acrylamide-modified inhibitor that covalently inhibits 23 kinases including MKNK2, MAP2K1/2/3/4/6/7, GAK, AAK1, BMP2K, MAP3K7, MAPKAPK5, GSK3A/B, MAPK1/3, SRC (IC50=4 nM), YES1, FGFR1 (IC50=54 nM), ZAK (MLTK), MAP3K1, LIMK1 and RSK2.

物理化学性质&存储条件

分子量 463.97
分子式 C24H26ClN7O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(2-((5-chloro-2-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)amino)phenyl)acrylamide

参考文献

1. Rao S, et al. J Biol Chem. 2019 May 24;294(21):8664-8673.

2. Rao S, et al. Cell Chem Biol. 2019 Jun 20;26(6):818-829.e9.

3. Guangyan Du, et al. J Med Chem. 2020 Feb 27;63(4):1624-1641.

4. Gurbani D, et al. Front Mol Biosci. 2020 May 19;7:81.

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