SM04755 | CLK inhibitor | Probechem Biochemicals

Chemical Structure : SM04755

CAS No.: 1428064-91-8

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SM04755 (SM 04755, Teplinovivint)

货号: PC-21435Not For Human Use, Lab Use Only.

Teplinovivint (SM04755) is a small molecule canonical Wnt signaling inhibitor, potently inhibited CLK2, CLK3, and DYRK1A with IC50 of 5.0 nM, 48.6 nM and 3.5 nM, respectively.

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5 mg	￥2280	In stock
10 mg	￥3680	In stock
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生物&药学活性

Teplinovivint (SM04755) is a small molecule canonical Wnt signaling inhibitor, potently inhibited CLK2, CLK3, and DYRK1A with IC50 of 5.0 nM, 48.6 nM and 3.5 nM, respectively.
SM04755 inhibits inflammation and promoted in vivo tendon healing in chronic and delayed‐treatment models of tendinopathy in rats.
SM04755 dose‐dependently inhibits the CLK‐mediated phosphorylation of SRSF1, SRSF4, SRSF5, and SRSF6 in rTDSCs and hMSCs.
SM04755 induces tenocyte differentiation, reduce tendon‐destroying proteases, and decrease inflammatory cytokine production.

物理化学性质&存储条件

分子量	442.52
分子式	C25H26N6O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(6-methoxypyridin-3-yl)-5-{5-[(piperidin-1-yl)methyl]pyridin-3-yl}-1H-indazole-3-carboxamide

参考文献

1. Deshmukh V, et al. Osteoarthr Cartil. 2019;27(9):1‐14.

2. Vishal Deshmukh, et al. J Orthop Res. 2021 Sep;39(9):2048-2061.

SM04755 (SM 04755, Teplinovivint)

生物&药学活性

物理化学性质&存储条件

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SM04755 (SM 04755, Teplinovivint)

生物&药学活性

物理化学性质&存储条件

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