SM-06-09

Chemical Structure : SM-06-09

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货号: PC-26932Not For Human Use, Lab Use Only.

SM-06-09 is a highly potent, selective HDAC6 inhibitor with IC50 of 0.49 nM, displays 35-fold selectivity over HDAC10 and >100-fold over all other HDACs.

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生物&药学活性

SM-06-09 is a highly potent, selective HDAC6 inhibitor with IC50 of 0.49 nM, displays 35-fold selectivity over HDAC10 and >100-fold over all other HDACs.
SM-06-09 inhibits total deacetylase activity in the RAW264.7 murine macrophage cell line with IC50 of 1.25-2.5 uM, inhibits nearly 85% of the total HDAC activity at 10 uM.
SM-06-09 enhances macrophage phagocytosis, antigen presentation, and T-cell activation in vitro.
SM-06-09 suppresses tumor growth and promoted M1-like TAM polarization in syngeneic melanoma model.
The combination of SM-06-09 and anti-PD-1 enhances the tumor immune landscape for immune-mediated tumor killing.

物理化学性质&存储条件

分子量	367.33
分子式	C16H13N7O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-Hydroxy-5-(2-(5-oxo-4-(quinolin-3-yl)-4,5-dihydro-1H-tetrazol-1-yl)ethyl)isoxazole-3-carboxamide

参考文献

1. Nithya Gajendran, et al. J Med Chem. 2026 May 29. doi: 10.1021/acs.jmedchem.5c02453.

SM-06-09

生物&药学活性

物理化学性质&存储条件

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SM-06-09

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物理化学性质&存储条件

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