SLx-4090 |CAS:913541-47-6 Probechem Biochemicals

Chemical Structure : SLx-4090

CAS No.: 913541-47-6

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SLx-4090 (KD-026;SLx4090)

货号: PC-60674Not For Human Use, Lab Use Only.

SLx-4090 (KD-026) is a novel potent, selective and orally active enterocytic microsomal triglyceride transfer protein (MTP) inhibitor that inhibits only MTP localized to enterocytes with IC50 of 6 nM.

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5 mg	￥2280	In stock
25 mg	￥4680	In stock
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生物&药学活性

SLx-4090 (KD-026) is a novel potent, selective and orally active enterocytic microsomal triglyceride transfer protein (MTP) inhibitor that inhibits only MTP localized to enterocytes with IC50 of 6 nM.
SLx-4090 inhibits apolipoprotein B (IC50=9.6 nM) but not apolipoprotein A1 secretion in Caco-2 cells.
SLx-4090 reduces postprandial lipids in rats with ED50 of 7 mg/kg, decreases the body weight gain and increases HDL-C in ApoE(−/−) mice.

物理化学性质&存储条件

分子量	546.546
分子式	C31H25F3N2O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4'-Trifluoromethyl-6-methoxy-biphenyl-2-ylcarboxamido)-1,2,3,4-tetrahydroisoquinoline-2-carboxylic acid phenyl ester

参考文献

1. Kim E, et al. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85.

SLx-4090 (KD-026;SLx4090)

生物&药学活性

物理化学性质&存储条件

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SLx-4090 (KD-026;SLx4090)

生物&药学活性

物理化学性质&存储条件

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