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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Estrogen Receptor/ERR-SLU-PP-332
SLU-PP-332

Chemical Structure : SLU-PP-332

CAS No.: 303760-60-3

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SLU-PP-332

货号: PC-20416Not For Human Use, Lab Use Only.

SLU-PP-332 is a potent, selective pan ERRα/β/γ agonist with EC50 of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, in full-length ERR cell-based cotransfection/reporter assays.

规格 价格 库存 数量
5 mg ￥780 In stock
10 mg ￥1180 In stock
25 mg ￥2180 In stock
50 mg ￥3580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SLU-PP-332 is a potent, selective pan ERRα/β/γ agonist with EC50 of 98, 230 and 430 nM for ERRα, ERRβ and ERRγ, in full-length ERR cell-based cotransfection/reporter assays.
SLU-PP-332 displays a degree of ERRα selectivity with 4.4-fold selectivity for ERRα over ERRγ and 2.3-fold ERRα over ERRβ.
SLU-PP-332 also displays activity at all ERRs in a Gal4-ERR LBD chimeric cotransfection assay, SLU-PP-332 is more potent at ERRα than ERRβ and ERRγ.
SLU-PP-332 is selective for the ERRs, does not alter the activity of either ERα or ERβ, or other nuclear receptors in cotransfection assays.
SLU-PP-332 (0.1-5 uM) increases the expression of an ERR target gene (pyruvate dehydrogenase kinase 4 (Pdk4)) and enhances mitochondrial respiration in C2C12 myocytes.
SLU-PP-332 (50 mg/kg, b.i.d, i.p.) increases oxidative fibers in skeletal muscle and improves exercise endurance in C57BL/6J mice.
SLU-PP-332 induces acute aerobic exercise genetic program in skeletal muscles, induces Ddit4 expression and enhances exercise endurance in an ERRα-dependent manner.

物理化学性质&存储条件

分子量 290.32
分子式 C18H14N2O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(E)-4-hydroxy-N'-(naphthalen-2-ylmethylene)benzohydrazide

参考文献

1. Billon C, et al. ACS Chem Biol. 2023 Mar 29. doi: 10.1021/acschembio.2c00720.

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