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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Estrogen Receptor/ERR-SLU-PP-1072
SLU-PP-1072

Chemical Structure : SLU-PP-1072

CAS No.: 2285432-57-5

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SLU-PP-1072

货号: PC-20417Not For Human Use, Lab Use Only.

SLU-PP-1072 is a potent, selective, dual ERRα/γ inverse agonist, inhibits ERRα- and ERRγ-dependent transcription in cotransfection assays with IC50 of 4.8 and 0.9 uM.

规格 价格 库存 数量
5 mg ￥1380 In stock
10 mg ￥2180 In stock
25 mg ￥3880 In stock
50 mg ￥5980 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SLU-PP-1072 is a potent, selective, dual ERRα/γ inverse agonist, inhibits ERRα- and ERRγ-dependent transcription in cotransfection assays with IC50 of 4.8 and 0.9 uM.
SLU-PP-1072 does not inhibit ERRβ, does not display estrogen receptor activity.
SLU-PP-1072 alters PCa cell metabolism and gene expression, resulting in cell cycle dysregulation and increased apoptosis without acute mitochondrial uncoupling activity.
SLU-PP-1072 is a unique chemical tool to evaluate the pharmacology of ERRα and ERRγ.

物理化学性质&存储条件

分子量 336.37
分子式 C18H12N2O3S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(benzo[d]thiazol-6-yl)-5-(4-hydroxyphenyl)furan-2-carboxamide

参考文献

1. Emmalie Schoepke, et al. ACS Chem Biol. 2020 Sep 18;15(9):2338-2345.

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