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首页-小分子抑制剂&激动剂-Nuclear Receptor/Transcription Factor-Keap1-Nrf2-SLOS-1811-06 tR1
SLOS-1811-06 tR1

Chemical Structure : SLOS-1811-06 tR1

CAS No.: 2797998-72-0

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SLOS-1811-06 tR1

货号: PC-26889Not For Human Use, Lab Use Only.

SLOS-1811-06 tR1 is a potent, small molecule activator of NRF2 with EC50 of 0.98 nM in ARE-luciferase reporter assays, shows inhibitory activity of NRF2-KEAP1 with IC50 of 0.17 nM in BRET assays, protects hiPSC-derived RGCs from hypoxia/reoxygenation injury.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SLOS-1811-06 tR1 is a potent, small molecule activator of NRF2 with EC50 of 0.98 nM in ARE-luciferase reporter assays, shows inhibitory activity of NRF2-KEAP1 with IC50 of 0.17 nM in BRET assays, protects hiPSC-derived RGCs from hypoxia/reoxygenation injury.

物理化学性质&存储条件

分子量 542.67
分子式 C27H30N2O6S2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(2R,3S)-3-(5-acetylthiophen-2-yl)-3-(3-(((R)-4-ethyl-1,1-dioxido-3,4-dihydro-2H-pyrido[4,3-b][1,4,5]oxathiazepin-2-yl)methyl)-4-methylphenyl)-2-methylpropanoic acid

参考文献

1. Miyabe T, et al. Exp Eye Res. 2026 May 19:111078.

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