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首页-小分子抑制剂&激动剂-Immunology/Inflammation-Sphingosine kinase (SphK)-SLM6071469
SLM6071469

Chemical Structure : SLM6071469

CAS No.: 2676896-83-4

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SLM6071469 (SM 6071469)

货号: PC-49707Not For Human Use, Lab Use Only.

SLM6071469 (SLM 6071469) is a potent, highly selective sphingosine kinase 2 (Sphk2) inhibitor with Ki value of 89 nM (hSphk2), 73-fold selectivity over hSphk1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    SLM6071469 (SLM 6071469) is a potent, highly selective sphingosine kinase 2 (Sphk2) inhibitor with Ki value of 89 nM (hSphk2), 73-fold selectivity over hSphk1.
    SLM6071469 shows improved potency and selectivity compared with SLM6031434.
    SLM6071469 inhibited SphK2 in vitro using recombinant protein and in yeast, SLM6071469 (10 mg/kg, i.p.) increased blood S1P levels in C57BL/6 mice.

    物理化学性质&存储条件

    分子量 499.42
    分子式 C22H19F6N5O2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    (S)-2-(3-(3-(trifluoromethyl)-4-((4-(trifluoromethyl)benzyl)oxy)phenyl)-1,2,4-oxadiazol-5-yl)pyrrolidine-1-carboximidamide

    参考文献

    1. Sibley CD, et al. J Med Chem. 2020 Feb 13;63(3):1178-1198.

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