SLM6031434 | SphK2 inhibitor | Probechem Biochemicals

Chemical Structure : SLM6031434

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SLM6031434 (SLM 6031434)

货号: PC-49706Not For Human Use, Lab Use Only.

SLM6031434 (SLM 6031434) is a potent, highly selective sphingosine kinase 2 (Sphk2) inhibitor with Ki value of 340 nM (hSphk2), 23-fold selectivity over hSphk1.

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生物&药学活性

SLM6031434 (SLM 6031434) is a potent, highly selective sphingosine kinase 2 (Sphk2) inhibitor with Ki value of 340 nM (hSphk2), 23-fold selectivity over hSphk1.
SLM6031434 inhibits mSphk2 with Ki of 400 nM, with no activity against mSphk1.
SLM6031434 dose-dependently increased Smad7 expression and ameliorated the expression of Col1, FN-1 and CTGF in primary renal fibroblasts.
SLM6031434 demonstrated anti-fibrotic potential in unilateral ureter obstruction (UUO), a model for progressive renal fibrosis.

物理化学性质&存储条件

分子量	453.51
分子式	C22H30F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2S)-2-[3-[4-(Octyloxy)-3-(trifluoromethyl)phenyl]-1,2,4-oxadiazol-5-yl]-1-pyrrolidinecarboximidamide

参考文献

1. Sibley CD, et al. J Med Chem. 2020 Feb 13;63(3):1178-1198.

2. Schwalm S, et al. Cell Signal. 2021 Mar;79:109881.

3. Kharel Y, et al. Biochem. J 2012, 447, 149–157.

SLM6031434 (SLM 6031434)

生物&药学活性

物理化学性质&存储条件

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SLM6031434 (SLM 6031434)

生物&药学活性

物理化学性质&存储条件

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