SLLN-15 | CAS 2403650-93-9 Probechem Biochemicals

Chemical Structure : SLLN-15

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SLLN-15 (Autophagy inducer SLLN-15)

货号: PC-36107Not For Human Use, Lab Use Only.

SLLN-15 (Autophagy inducer SLLN-15) is a potent, orally available inducer of autophagy that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models, promotes AURKA degradation.

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生物&药学活性

SLLN-15 (Autophagy inducer SLLN-15) is a potent, orally available inducer of autophagy that selectively activated cytostatic macroautophagy/autophagy in TNBC preclinical models, promotes AURKA degradation.
SLLN-15 induced a dose-dependent anti-proliferative activity in the TNBC cell lines MDA-MB-231 and BT-20 via induction of autophagy and autophagic flux, associated with a selective inhibition of AKT-MTOR signaling.
SLLN-15-induced autophagy in TNBC cells was also associated with decreased AURKA expression decreased AKT phosphorylation and subsequent blockage of the AKT-MTOR pathway.
SLLN-15 demonstrates anticancer and anti-metastatic activity in mice bearing TNBC.

物理化学性质&存储条件

分子量	507.362
分子式	C19H23N7Se2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-N2-(4-selenomorpholinophenyl)-N6-(tetrahydroselenophen-3-yl)-9H-purine-2,6-diamine

参考文献

1. Chang CH, et al. Autophagy. 2019 Feb 17. doi: 10.1080/15548627.2019.1582951.

SLLN-15 (Autophagy inducer SLLN-15)

生物&药学活性

物理化学性质&存储条件

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SLLN-15 (Autophagy inducer SLLN-15)

生物&药学活性

物理化学性质&存储条件

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