SLCB050 | DX2-p14/ARF inhibitor | Probechem Biochemicals

Chemical Structure : SLCB050

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SLCB050 (SLC-B050)

货号: PC-23229Not For Human Use, Lab Use Only.

SLCB050 is a specific small molecule inhibitor of AIMP2-DX2-p14/ARF Interaction, inhibits lung cancer progression.

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250 mg		Get quote

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生物&药学活性

SLCB050 is a specific small molecule inhibitor of AIMP2-DX2-p14/ARF Interaction, inhibits lung cancer progression.
SLCB050 also blocks the interaction of DX2 and AIMP2, but not on p53-AIMP2 or DX2 binding and p14/ARF.
SLCB050 reduced the viability of human lung cancer cells, especially small cell lung cancer cells, in a p14/ARF-dependent manner.
SLCB050 inhibits tumor progression in mouse model of K-Ras-driven lung tumorigenesis, ectopic expression of DX2 induced small cell and non–small cell lung cancers.

物理化学性质&存储条件

分子量	366.37
分子式	C21H18O6
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-8,8-dimethyl-2-oxo-7,8-dihydro-2H,6H-pyrano[3,2-g]chromen-7-yl (E)-3-(furan-2-yl)acrylate

参考文献

1. Oh AY, et al. Cancer Res. 2016 Aug 15;76(16):4791-804.

SLCB050 (SLC-B050)

生物&药学活性

物理化学性质&存储条件

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SLCB050 (SLC-B050)

生物&药学活性

物理化学性质&存储条件

参考文献

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