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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-Ribosomal S6 Kinase (RSK)-SL0101
SL0101

Chemical Structure : SL0101

CAS No.: 77307-50-7

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SL0101 (SL-0101, SL 0101-1)

货号: PC-70183Not For Human Use, Lab Use Only.

SL0101 (SL 0101-1) is the first specific inhibitor of RSK (p90 ribosomal S6 kinase) with IC50 of 89 nM for RSK2.

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1 mg ￥1780 In stock
5 mg ￥4580 In stock
10 mg ￥7580 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SL0101 (SL 0101-1) is the first specific inhibitor of RSK (p90 ribosomal S6 kinase) with IC50 of 89 nM for RSK2.
SL0101 does not inhibit upstream kinases such as MEK, Raf and PKC.
SL0101 inhibits the growth of MCF-7 human breast cancer cells with no effect on the normal breast cell line.

物理化学性质&存储条件

分子量 516.46
分子式 C25H24O12
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

3-[(3,4-Di-O-acetyl-6-deoxy-a-L-mannopyranosyl)oxy]-5,7-dihydroxy-2-(4-hydroxyphenyl)-4H-1-benzopyran-4-one

参考文献

1. Smith JA, et al. Cancer Res. 2005 Feb 1;65(3):1027-34.

2. Flynn JM, et al. Am J Physiol Endocrinol Metab. 2008 Mar;294(3):E589-99.

3. Harada K, et al. J Biol Chem. 2010 Jul 30;285(31):24044-54.

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