SL-145 | Hsp90 inhibitor | Probechem Biochemicals

Chemical Structure : SL-145

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SL-145 (SL145)

货号: PC-38632Not For Human Use, Lab Use Only.

SL-145 is a novel C-terminal HSP90 inhibitor, induces apoptosis in TNBC cells via the suppression of oncogenic AKT, MEK/ERK, and JAK2/STAT3 signaling.

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生物&药学活性

SL-145 is a novel C-terminal HSP90 inhibitor, induces apoptosis in TNBC cells via the suppression of oncogenic AKT, MEK/ERK, and JAK2/STAT3 signaling.
SL-145 targets the C-terminal domain of HSP90, does not trigger the heat shock response (HSR), compared to other inhibitors.
SL-145 markedly downregulated AKT, MEK, and ERK expression and reduced their phosphorylation.
SL-145 impedes tumor growth by targeting breast cancer stem cell (BCSC)-like properties in vitro and in vivo, impairs metastatic spread from primary tumors via dysregulation of STAT3 signaling.

物理化学性质&存储条件

分子量	445.515
分子式	C27H27NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(6,7-dimethoxyquinolin-4-yl)(2,2-dimethyl-2H-chromen-6-yl)methyl cyclopropanecarboxylate

参考文献

1. Ji Young Kim, et al. Oncogene. 2022 May 2. doi: 10.1038/s41388-022-02269-y.

SL-145 (SL145)

生物&药学活性

物理化学性质&存储条件

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SL-145 (SL145)

生物&药学活性

物理化学性质&存储条件

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