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首页-小分子抑制剂&激动剂-Others-Other Targets-SKOG102
SKOG102

Chemical Structure : SKOG102

CAS No.: 21062-28-2

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SKOG102 (SKOG 102)

货号: PC-21701Not For Human Use, Lab Use Only.

SKOG102 is a specific, brain penetrant small molecule inhibitor of protein transcription factor OLIG2 with IC50 of 1.04 uM, impacts OLIG2 DNA binding ability, inhibits human GBM4 and GBM8 cells with IC50 of 1-2 uM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

SKOG102 is a specific, brain penetrant small molecule inhibitor of protein transcription factor OLIG2 with IC50 of 1.04 uM, impacts OLIG2 DNA binding ability, inhibits human GBM4 and GBM8 cells with IC50 of 1-2 uM.
SKOG102 affects expression of direct genetic targets of OLIG2.
SKOG102 (20 mg/kg) significantly attenuated tumor growth in in vivo studies to a GBM patient derived cancer stem cell (GBM4 line) based orthotopic model.

物理化学性质&存储条件

分子量 422.36
分子式 C19H25Cl2N7
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

1-(3,4-dichlorophenyl)-3-(4-((1-ethyl-3-piperidyl)amino)-6-methyl-2-pyrimidinyl)guanidine

参考文献

1. Igor F Tsigelny, et al. Oncotarget. 2017 Apr 4;8(14):22370-22384.

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