SKLB325 | JMJD6 inhibitor | Probechem Biochemicals

Chemical Structure : SKLB325

CAS No.: 1612138-91-6

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SKLB325 (SKLB 325, SKLB-325)

货号: PC-72265Not For Human Use, Lab Use Only.

SKLB325 (SKLB 325) is a potential inhibitor for JMJD6 with Kd of 0.755 uM by SPR assays, biochemical IC50 of 0.78 uM.

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5 mg	￥3280	In stock
10 mg	￥5280	In stock
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生物&药学活性

SKLB325 (SKLB 325) is a potential inhibitor for JMJD6 with Kd of 0.755 uM by SPR assays, biochemical IC50 of 0.78 uM.
SKLB325 suppresses proliferation, induces apoptosis in ovarian cancer cells, inhibits angiogenesis in HUVECs, and inhibits migration in ovarian cancer cells and HUVECs in vitro.
SKLB325 upregulates the expression of p53 and its downstream effectors at both the mRNA and protein levels in vitro.
SKLB325 exhibits strong therapeutic effects on intraperitoneal dissemination xenograft mouse models, upregulates the expression of p53 as well as its downstream effectors at the protein level in vivo.

物理化学性质&存储条件

分子量	244.254
分子式	C12H12N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 Month
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	2-(2-(2-hydroxybenzylidene) hydrazinyl)-6-methylpyrimidin-4-ol

参考文献

1. Zheng H, et al. Signal Transduct Target Ther. 2019 Jul 26;4:24.

2. Zhang C, et al. Clin Transl Med. 2021 Feb;11(2):e328.

SKLB325 (SKLB 325, SKLB-325)

生物&药学活性

物理化学性质&存储条件

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SKLB325 (SKLB 325, SKLB-325)

生物&药学活性

物理化学性质&存储条件

参考文献

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