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首页-小分子抑制剂&激动剂-Tyrosine Kinase-FLT3-SKLB1028
SKLB1028

Chemical Structure : SKLB1028

CAS No.: 1350544-93-2

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SKLB1028 (Ruserontinib)

货号: PC-23460Not For Human Use, Lab Use Only.

SKLB1028 (Ruserontinib) is a potent, oral multikinase inhibitor of EGFR, FLT3 and Abl with IC50 of 55 nM (FLT3), potently inhibits the wild-type and L858R-mutant EGFR with IC50 values of 31 nM and 4 nM, respectively.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

SKLB1028 (Ruserontinib) is a potent, oral multikinase inhibitor of EGFR, FLT3 and Abl with IC50 of 55 nM (FLT3), potently inhibits the wild-type and L858R-mutant EGFR with IC50 values of 31 nM and 4 nM, respectively.
SKLB1028 (Ruserontinib) displays exceptional activity in FLT3‐driven AML.
SKLB1028 has strong anti‐leukemia effects both in vivo and in vitro.

物理化学性质&存储条件

分子量 443.56
分子式 C24H29N9
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

9-Isopropyl-N2-(4-(4-methylpiperazin-1-yl)phenyl)-N8-(pyridin-3-yl)-9H-purine-2,8-diamine

参考文献

1. Cao ZX, et al. Leukemia. 2012 Aug;26(8):1892-5.

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