SKLB06489 | Type I PRMTs inhibitor | Probechem Biochemicals

Chemical Structure : SKLB06489

加入收藏

SKLB06489 (SKLB-06489)

货号: PC-25966Not For Human Use, Lab Use Only.

SKLB06489 is a potent, selective type I PRMTs inhibitor with IC50 of 64.55, 4.21, and 51.27 nM for PRMT1, PRMT6, and PRMT8 respectively.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

SKLB06489 is a potent, selective type I PRMTs inhibitor with IC50 of 64.55, 4.21, and 51.27 nM for PRMT1, PRMT6, and PRMT8 respectively.
SKLB06489 dose-dependently inhibits cell proliferation and colony formation with IC50 values in the low micromolar range in TNBC cell lines MDA-MB-231, Hs578T, and BT549.
SKLB06489 (40, 80 mg·kg-1·d-1, i.g. for 33 days) dose-dependently suppressed tumor growth in MDA-MB-231 subcutaneous xenograft models.
SKLB06489 inhibited TNBC proliferation by impairing DNA replication, compromising DNA damage repair, and ultimately inducing G0/G1-phase cell cycle arrest and apoptosis.
SKLB06489 (5, 10 μΜ) dose-dependently enhanced intracellular cholesterol efflux in MDA-MB-231 cells and Hs578T cells via upregulation of the ATP-binding cassette transporter A1 (ABCA1) and ATP-binding cassette transporter G1 (ABCG1), thereby disrupting cholesterol metabolic homeostasis.

物理化学性质&存储条件

分子量	419.57
分子式	C25H33N5O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(4-(3-((methyl(2-(methylamino)ethyl)amino)methyl)-1H-indazol-5-yl)phenyl)cyclohexanecarboxamide

参考文献

1. Zhou SY, et al. Acta Pharmacol Sin. 2026 Jan 16. doi: 10.1038/s41401-025-01713-5.

SKLB06489 (SKLB-06489)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

SKLB06489 (SKLB-06489)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.