SKLB-Y13

Chemical Structure : SKLB-Y13

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货号: PC-25345Not For Human Use, Lab Use Only.

SKLB-Y13 is the first, selective small-molecule inhibitor targeting of the YTHDF1 m6A-binding pocket with IC50 of 0.76 uM, has selectivity for YTHDF1 over YTH family proteins.

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生物&药学活性

SKLB-Y13 is the first, selective small-molecule inhibitor targeting of the YTHDF1 m6A-binding pocket with IC50 of 0.76 uM, has selectivity for YTHDF1 over YTH family proteins.
SKLB-Y13 interacts with YTHDF1-specific residues Tyr397 and Trp470.
SKLB-Y13 disrupts YTHDF1-PRPF6 mRNA interaction in an m6A-dependent manner in cells, thereby impairing the translation of PRPF6 and inhibiting BC proliferation while promoting apoptosis.
SKLB-Y13 exerts anti-BC activity in vitro and in vivo by specifically inhibiting PRPF6 translation.

物理化学性质&存储条件

分子量	514.43
分子式	C23H21Cl2N7OS
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
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Solubility	10 mM in DMSO
Chemical Name/SMILES	2-((5-chloro-2-(1-methyl-1H-pyrazol-5-yl)pyrimidin-4-yl)amino)-6-(2-chlorobenzyl)-4,5,6,7-tetrahydrothieno[2,3-c]pyridine-3-carboxamide

参考文献

1. Wu Y, et al. Angew Chem Int Ed Engl. 2025 Aug 19:e202509316.

SKLB-Y13

生物&药学活性

物理化学性质&存储条件

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SKLB-Y13

生物&药学活性

物理化学性质&存储条件

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