SKLB-C05 |CAS 2300981-68-2 Probechem Biochemicals

Chemical Structure : SKLB-C05

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SKLB-C05 (TOPK inhibitor SKLB-C05)

货号: PC-35916Not For Human Use, Lab Use Only.

SKLB-C05 is a novel selective, orally active TOPK inhibitor with IC50 of 0.5 nM, shows excellent cytotoxicity and anti-migration and invasion activity on TOPK high-expressing CRC cells and induces cell apoptosis.

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生物&药学活性

SKLB-C05 is a novel selective, orally active TOPK inhibitor with IC50 of 0.5 nM, shows excellent cytotoxicity and anti-migration and invasion activity on TOPK high-expressing CRC cells and induces cell apoptosis.
SKLB-C05 exhibits markedly prioritized inhibitory activity on TOPK-positive CRC cells than TOPK-negative cells (HCT116 cell IC50=96 nM).
SKLB-C05 inhibits TOPK downstream signaling including ERK1/2, p38, and JNK1/2/3, as well as downregulation of FAK/Src- MMP signaling.
SKLB-C05 dramatically attenuates CRC tumor xenograft growth and completely suppressed hepatic metastasis of HCT116 cells (20 and 10 mg/kg/day).

物理化学性质&存储条件

分子量	394.899
分子式	C23H23ClN2O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-(4-(1-aminopropan-2-yl)phenyl)-2-hydroxy-4-methylphenanthridin-6(5H)-one hydrochloride

参考文献

1. Gao T, et al. Cancer Lett. 2018 Dec 24. pii: S0304-3835(18)30737-7.

SKLB-C05 (TOPK inhibitor SKLB-C05)

生物&药学活性

物理化学性质&存储条件

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SKLB-C05 (TOPK inhibitor SKLB-C05)

生物&药学活性

物理化学性质&存储条件

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